The audio clock is taken from the TLV320AIC3104, so disconnecting it would not allow the analogs to run, either. I guess this could be changed in the PRU code, so that it sleeps for a set amount of time instead, but I do not think we are going to add this feature ourselves, as it would make maintenance difficult later down the line.
I2C2 is used by the TLV320AIC3104 while I2C1 is made available on the extra header.
In fact, the I2C is used for the TLV320AIC3104 only at initialization time (that is: every time you start a program), but you should be able to use another device on the same bus as long as a) you do not use it at the same time and b) it has a different I2C address.
The MPR121 demo connects the MPR to I2C1 over the header.
Also note that Bela's "analog" ADC and DAC are served over the SPI bus, not I2C.